Lipom (Lipoma, Yağ Bezesi, Lipomatozis) ve Yüksek Tansiyon

Lipom nedir?

Lipom (lipoma, yağ bezesi), vücuttaki yağ dokusundan köken alan ve malign (habis, kötü huylu) olmayan tümörlerdir (ur, neoplazm).

---

Lipomatoz (Lipomatosis) vücutta birden fazla lipomun bulunmasıdır.

Bazen genetik sendromların parçası olarak ortaya çıkar:

• Madelung hastalığı / Madelung sendromu (multiple symmetric lipomatosis, benign symmetric lipomatosis)
• Schimmelpenning sendromu (Linear nevus sebaceous syndrome, Schimmelpenning-Feuerstein-Mims syndrome, Feuerstein-Mims syndrome, sebaceous nevus syndrome, Solomon syndrome, Jadassohn’s nevus phakomatosis)

---

Lipomlar ve yüksek tansiyon

Lipomları olan 7,868  kişinin incelendiği bir araştırmada, lipomları olanlarda metabolik sendromun (yüksek tansiyon, obezite, dislipidemi ve tip 2 diyabet) daha sık görüldüğü tespit edilmiştir.

Lipomatoz sendromlarında da eşlik eden yüksek tansiyon sık görülür.

---

Kaynaklar:

Lipomas are associated with a higher prevalence of metabolic syndrome components: a multicenter cross-sectional study. Front Endocrinol (Lausanne). 2025 Dec 2:16:1721570. doi: 10.3389/fendo.2025.1721570.

Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis. J Clin Med. 2021 Mar 21;10(6):1292. doi: 10.3390/jcm10061292. Ücretsiz Tam Makale erişimi

Mosaic KRAS mutation in a patient with encephalocraniocutaneous lipomatosis and renovascular hypertension. Am J Med Genet A. 2018 Nov;176(11):2523-2527. doi: 10.1002/ajmg.a.40349.

Multiple symmetric lipomatosis (Madelung’s disease) with symptoms and signs of hypertension, lipodystrophy, and dyspnea: A case report and literature review. Clin Case Rep. 2021 Jun 24;9(6):e04288. doi: 10.1002/ccr3.4288. Ücretsiz Tam Makale erişimi

A postzygotic KRAS mutation in a patient with Schimmelpenning syndrome presenting with lipomatosis, renovascular hypertension, and diabetes mellitus. J Hum Genet. 2019 Feb;64(2):177-181. doi: 10.1038/s10038-018-0539-3.

MRI Diagnosis of Obesity-Related Spinal Epidural Lipomatosis. Can J Neurol Sci. 2020 Jan;47(1):124-125. doi: 10.1017/cjn.2019.301.

A Case Report of Madelung’s Disease. Arch Plast Surg. 2023 Oct 5;50(5):463-467. doi: 10.1055/a-2122-6121. Ücretsiz Tam Makale erişimi

Shedding Light on Multiple Symmetric Lipomatosis: An Overlooked Syndrome in the Evaluation of Obesity. Am J Case Rep. 2023 Dec 1:24:e941751. doi: 10.12659/AJCR.941751. Ücretsiz Tam Makale erişimi

From Cushing syndrome to lipodystrophy: an ultrarare case of MFN2-associated lipomatosis. Pol Arch Intern Med. 2023 Jun 23;133(6):16495. doi: 10.20452/pamw.16495. Ücretsiz Tam Makale erişimi

Radiologic manifestations of pelvic lipomatosis. Radiologe. 1977 Mar;17(3):130-5.

Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome. Spine J. 2019 Mar;19(3):493-500. doi: 10.1016/j.spinee.2018.07.022.

Rare etiology of obstructive uropathy: pelvic lipomatosis. Urol Int. 2010;84(2):239-41. doi: 10.1159/000277606.

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord. 2004 Dec:28 Suppl 4:S58-65. doi: 10.1038/sj.ijo.0802858.

Renal sinus lipomatosis: a report of twenty-six cases. Br J Urol. 1969 Jun;41(3):257-66. doi: 10.1111/j.1464-410x.1969.tb11881.x.

Madelung’s Disease as an Example of a Metabolic Disease Associated with Alcohol Abuse-Diagnostic Importance of Computed Tomography. Int J Environ Res Public Health. 2022 Apr 24;19(9):5168. doi: 10.3390/ijerph19095168. Ücretsiz Tam Makale erişimi

Long-term results following surgical treatment of benign symmetric lipomatosis (BSL). Int J Oral Maxillofac Surg. 2001 Dec;30(6):479-83. doi: 10.1054/ijom.2001.0162.